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1

Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome

Voorhees, Rebecca M, Weixlbaumer, Albert, Loakes, David, Kelley, Ann C, Ramakrishnan, V

Journal:

Nature Structural and Molecular Biology

Year:

2009

Language:

english

File:

PDF, 684 KB

english, 2009

2

The Synthesis of Bicyclic N4-Amino-2′-deoxycytidine Derivatives

David Loakes, Rita Bazzanini, Daniel M. Brown

Journal:

Helvetica Chimica Acta

Year:

1999

Language:

english

File:

PDF, 110 KB

english, 1999

3

The Syntheses of Pyrimido-pyridazinone and Pyrrolidino-pyrimidinone 2′-Deoxynucleoside Derivatives

David Loakes, Mao-Jun Guo, Ji-Chun Yang, Daniel M. Brown

Journal:

Helvetica Chimica Acta

Year:

2000

Language:

english

File:

PDF, 139 KB

english, 2000

4

ChemInform Abstract: Synthesis of a Hydrogen-Bond-Degenerate Tricyclic Pyrrolopyrimidine Nucleoside (XIII) and of Its 5′-Triphosphate (XIV).

David M. Williams, David Loakes, Daniel M. Brown

Journal:

Year:

1999

File:

PDF, 34 KB

1999

5

ChemInform Abstract: A Dimroth Rearrangement of Pyrimidine Nucleosides.

David Loakes, Daniel M. Brown, Stephen A. Salisbury

Journal:

Year:

1999

File:

PDF, 27 KB

1999

6

ChemInform Abstract: Synthesis of Reactive γ-Lactams Related to Penicillins and Cephalosporins.

Shameem H. Bhattia, Gareth M. Davies, Peter B. Hitchcock, David Loakes, Douglas W. Young

Journal:

Year:

2000

File:

PDF, 32 KB

2000

7

ChemInform Abstract: The Synthesis of Bicyclic N4-Amino-2′-deoxycytidine Derivatives.

David Loakes, Rita Bazzanini, Daniel M. Brown

Journal:

Year:

2000

Language:

english

File:

PDF, 36 KB

english, 2000

8

ChemInform Abstract: Synthesis of Tricyclic β-Lactams Related to Cephalosporins.

Nigel K. Capps, Gareth M. Davies, David Loakes, Douglas W. Young

Journal:

Year:

2001

File:

PDF, 30 KB

2001

9

The Synthesis and Reactions of N4-Amino-2′-deoxycytidine Derivatives

David Loakes, Daniel M. Brown

Journal:

Year:

2003

File:

PDF, 51 KB

2003

10

Synthesis and Enzymatic Incorporation of a Novel, Bicyclic Pyrimidine Nucleoside: A Thymidine Mimic.

David Loakes, Daniel M. Brown, Stephen A. Salisbury, Mark G. McDougall, Constantin Neagu, Satyam Nampalli, Shiv Kumar

Journal:

Year:

2003

File:

PDF, 59 KB

2003

11

ChemInform Abstract: Polymerase Engineering: Towards the Encoded Synthesis of Unnatural Biopolymers

David Loakes, Philipp Holliger

Journal:

Year:

2009

File:

PDF, 15 KB

2009

12

ChemInform Abstract: Nucleotides and Nucleic Acids — Oligo- and Polynucleotides

Journal:

Year:

2010

File:

PDF, 15 KB

2010

13

ChemInform Abstract: Nucleotides and Nucleic Acids, Oligo- and Polynucleotides

Journal:

Year:

2010

File:

PDF, 15 KB

2010

14

ChemInform Abstract: Nucleotides and Nucleic Acids: Oligo- and Polynucleotides

Journal:

Year:

2012

File:

PDF, 18 KB

2012

15

Synthesis and Some Biochemical Properties of a Novel 5,6,7,8-Tetrahydropyrimido[4,5-c]pyridazine Nucleoside

David Loakes, Daniel M. Brown, Stephen A. Salisbury, Mark G. McDougall, Constantin Neagu, Satyam Nampalli, Shiv Kumar

Journal:

Helvetica Chimica Acta

Year:

2003

Language:

english

File:

PDF, 161 KB

english, 2003

16

Synthesis of a hexahydro-2H-imidazo[4,5-g]isoquinolin-2-one derivative as an isostere of catecholamine-based selective dopamine D-1 antagonists

Clive V Denyer, Hazel Bunyan, David M Loakes, Jacqueline Tucker, Janet Gillam

Journal:

Year:

1995

Language:

english

File:

PDF, 535 KB

english, 1995

17

Synthesis of reactive γ-lactams related to penicillins and cephalosporins

Gareth M Davies, Peter B Hitchcock, David Loakes, Douglas W Young

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 244 KB

english, 1996

18

Anti-malarial activity of N6-modified purine analogues

Kathleen Too, Daniel M. Brown, Emily Bongard, Vanessa Yardley, Livia Vivas, David Loakes

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 227 KB

english, 2007

19

Synthesis and enzymatic incorporation of a novel, bicyclic pyrimidine nucleoside: a thymidine mimic

David Loakes, Daniel M Brown, Stephen A Salisbury, Mark G McDougall, Constantin Neagu, Satyam Nampalli, Shiv Kumar

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 170 KB

english, 2003

20

Cyclisation and rearrangement of N4-acylaminodeoxycytidines

David Loakes, Daniel M. Brown, Stephen A. Salisbury

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 213 KB

english, 1998

21

Reductive and catalytic rearrangements of 2-vinyl-1,3-thiazetidines

Nigel K Capps, Gareth M Davies, David Loakes, Douglas W Young

Journal:

Year:

1992

Language:

english

File:

PDF, 876 KB

english, 1992

22

Ultraviolet radiation drives methane emissions from terrestrial plant pectins

Andy R. McLeod, Stephen C. Fry, Gary J. Loake, David J. Messenger, David S. Reay, Keith A. Smith, Byung-Wook Yun

Journal:

New Phytologist

Year:

2008

Language:

english

File:

PDF, 228 KB

english, 2008

23

Molecular breeding of polymerases for amplification of ancient DNA

d'Abbadie, Marc, Hofreiter, Michael, Vaisman, Alexandra, Loakes, David, Gasparutto, Didier, Cadet, Jean, Woodgate, Roger, Pääbo, Svante, Holliger, Philipp

Journal:

Nature Biotechnology

Year:

2007

Language:

english

File:

PDF, 335 KB

english, 2007

24

Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution

Ghadessy, Farid J, Ramsay, Nicola, Boudsocq, François, Loakes, David, Brown, Anthony, Iwai, Shigenori, Vaisman, Alexandra, Woodgate, Roger, Holliger, Philipp

Journal:

Nature Biotechnology

Year:

2004

Language:

english

File:

PDF, 543 KB

english, 2004

25

Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose)

Eustermann, Sebastian, Brockmann, Christoph, Mehrotra, Pawan Vinod, Yang, Ji-Chun, Loakes, David, West, Stephen C, Ahel, Ivan, Neuhaus, David

Journal:

Nature Structural and Molecular Biology

Year:

2010

Language:

english

File:

PDF, 454 KB

english, 2010

26

The redox switch: dynamic regulation of protein function by cysteine modifications

Davide Spadaro, Byung-Wook Yun, Steven H. Spoel, Chengcai Chu, Yi-Qin Wang, Gary J. Loake

Journal:

Physiologia Plantarum

Year:

2010

Language:

english

File:

PDF, 549 KB

english, 2010

27

[Organophosphorus Chemistry] Organophosphorus Chemistry || Quinquevalent phosphorus acids

Allen, D W, Tebby, J C, Loakes, David

Year:

2011

Language:

english

File:

PDF, 4.49 MB

english, 2011

28

[Organophosphorus Chemistry] Organophosphorus Chemistry Volume 40 ||

Allen, D W, Tebby, J C, Loakes, David

Year:

2011

Language:

english

File:

PDF, 4.49 MB

english, 2011

29

[Organophosphorus Chemistry] Organophosphorus Chemistry Volume 40 || Phosphines and related P–C-bonded compounds

Allen, D W, Tebby, J C, Loakes, David

Year:

2011

Language:

english

File:

PDF, 905 KB

english, 2011

30

Transversion-enriched sequence saturation mutagenesis (SeSaM-Tv+): A random mutagenesis method with consecutive nucleotide exchanges that complements the bias of error-prone PCR

Tuck Seng Wong, Danilo Roccatano, David Loakes, Kang Lan Tee, Alexander Schenk, Bernhard Hauer, Ulrich Schwaneberg

Journal:

Biotechnology Journal

Year:

2008

Language:

english

File:

PDF, 337 KB

english, 2008

31

DNA conformation and its changes upon binding transcription factors

Masashi Suzuki, David Loakes, Naoto Yagi

Journal:

Advances in Biophysics

Year:

1996

Language:

english

File:

PDF, 1.04 MB

english, 1996

32

Roles of the polymerase and BRCT domains of Rev1 protein in translesion DNA synthesis in yeast in vivo

Chie Otsuka, Nozomu Kunitomi, Shigenori Iwai, David Loakes, Kazuo Negishi

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2005

Language:

english

File:

PDF, 323 KB

english, 2005

33

Binding of MutS protein to oligonucleotides containing a methylated or an ethylated guanine residue, and correlation with mutation frequency

Kentaro Taira, Shintaro Nakamura, Khota Nakano, Daisuke Maehara, Keinosuke Okamoto, Sakae Arimoto, David Loakes, Leroy Worth Jr, Roel M. Schaaper, Kohji Seio, Mitsuo Sekine, Kazuo Negishi, Tomoe Negis

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2008

Language:

english

File:

PDF, 602 KB

english, 2008

34

Use of yeast transformation by oligonucleotides to study DNA lesion bypass in vivo

Chie Otsuka, Keita Kobayashi, Naho Kawaguchi, Nozomu Kunitomi, Kei Moriyama, Yoshihiro Hata, Shigenori Iwai, David Loakes, Vladimir N. Noskov, Youri Pavlov, Kazuo Negishi

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2002

Language:

english

File:

PDF, 106 KB

english, 2002

35

[Organophosphorus Chemistry] Organophosphorus Chemistry Volume 40 || Phosphonium salts and P-ylides

Allen, D W, Tebby, J C, Loakes, David

Year:

2011

Language:

english

File:

PDF, 744 KB

english, 2011

36

[Organophosphorus Chemistry] Organophosphorus Chemistry Volume 40 || Nucleotides and nucleic acids; oligo- and polynucleotides

Allen, D W, Tebby, J C, Loakes, David

Year:

2011

Language:

english

File:

PDF, 1.32 MB

english, 2011

37

Stability and structure of DNA oligonucleotides containing non-specific base analogues

David Loakes, Fergal Hill, Daniel M. Brown, Stephen A. Salisbury

Journal:

Journal of Molecular Biology

Year:

1997

Language:

english

File:

PDF, 454 KB

english, 1997

38

A thymine-like base analogue forms wobble pairs with adenine in a Z-DNA duplex

Geertrui S Schuerman, Luc Van Meervelt, David Loakes, Daniel M Brown, Paul Kong Thoo Lin, Madeleine H Moore, Stephen A Salisbury

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 318 KB

english, 1998

39

Directed Evolution of DNA Polymerase, RNA Polymerase and Reverse Transcriptase Activity in a Single Polypeptide

Jennifer L. Ong, David Loakes, Szymon Jaroslawski, Kathleen Too, Philipp Holliger

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 1.42 MB

english, 2006

40

Darwinian chemistry: towards the synthesis of a simple cell

Loakes, David, Holliger, Philipp

Journal:

Molecular BioSystems

Year:

2009

Language:

english

File:

PDF, 904 KB

english, 2009

41

[Organophosphorus Chemistry] Organophosphorus Chemistry Volume 41 || Phosphine chalcogenides

Allen, David W, Loakes, David, Tebby, John C

Year:

2012

Language:

english

File:

PDF, 1.52 MB

english, 2012

42

[Organophosphorus Chemistry] Organophosphorus Chemistry Volume 41 || Quinquevalent phosphorus acids

Allen, David W, Loakes, David, Tebby, John C

Year:

2012

Language:

english

File:

PDF, 10.81 MB

english, 2012

43

[Organophosphorus Chemistry] Organophosphorus Chemistry Volume 41 || Phosphazenes

Allen, David W, Loakes, David, Tebby, John C

Year:

2012

Language:

english

File:

PDF, 2.28 MB

english, 2012

44

[Organophosphorus Chemistry] Organophosphorus Chemistry Volume 41 || Pentacoordinated and hexacoordinated compounds

Allen, David W, Loakes, David, Tebby, John C

Year:

2012

Language:

english

File:

PDF, 1.84 MB

english, 2012

45

Evolving a Polymerase for Hydrophobic Base Analogues

Loakes, David, Gallego, José, Pinheiro, Vitor B., Kool, Eric T., Holliger, Philipp

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 605 KB

english, 2009

46

Improved Allelic Differentiation Using Sequence‐Specific Oligonucleotide Hybridization Incorporating an Additional Base‐Analogue Mismatch

Burgner, David, D'Amato, Mauro, Kwiatkowski, Dominic P., Loakes, David

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2004

Language:

english

File:

PDF, 432 KB

english, 2004

47

[Organophosphorus Chemistry] Organophosphorus Chemistry Volume 41 || Nucleotides and nucleic acids; oligo- and polynucleotides

Allen, David W, Loakes, David, Tebby, John C

Year:

2012

Language:

english

File:

PDF, 1.62 MB

english, 2012

48

Determinants of cofactor binding to DNA methyltransferases: insights from a systematic series of structural variants of S-adenosylhomocysteine

Cohen, Helen M., Griffiths, Andrew D., Tawfik, Dan S., Loakes, David

Journal:

Organic & Biomolecular Chemistry

Year:

2005

Language:

english

File:

PDF, 254 KB

english, 2005

49

[Organophosphorus Chemistry] Organophosphorus Chemistry Volume 41 || Phosphines and related P–C-bonded compounds

Allen, David W, Loakes, David, Tebby, John C

Year:

2012

Language:

english

File:

PDF, 1.10 MB

english, 2012

50

[Organophosphorus Chemistry] Organophosphorus Chemistry Volume 41 || Abbreviations

Allen, David W, Loakes, David, Tebby, John C

Year:

2012

Language:

english

File:

PDF, 101 KB

english, 2012